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Physiological functions of NHR-8

NHR-8 is required for gut function and may respond to the food signal.

The nhr-8 gene mutants have abnormally low resistance to the toxins colchicine and chloroquine.This resembles the regulation of protective metabolic enzymes by xenobiotic-sensing nuclear receptors.

NHR-8 may thus mediate a subset of the resistance traits promoted by PGP-3.

Possible applications of NHR-8 LBD

This LBD can be fused with different DBDs forming a composite hormone receptor for ligand regulated expression of specific genes and can also be a sensor for various lipid natured molecules.

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